# UMLS::Similarity::batet.pm # # Module implementing the semantic relatedness measure described # by Batet, et al. (2011) # # Copyright (c) 2004-2015, # # Bridget T McInnes, University of Minnesota, Twin Cities # bthomson at cs.umn.edu # # Siddharth Patwardhan, University of Utah, Salt Lake City # sidd at cs.utah.edu # # Serguei Pakhomov, University of Minnesota, Twin Cities # pakh002 at umn.edu # # Ted Pedersen, University of Minnesota, Duluth # tpederse at d.umn.edu # # This program is free software; you can redistribute it and/or # modify it under the terms of the GNU General Public License # as published by the Free Software Foundation; either version 2 # of the License, or (at your option) any later version. # # This program is distributed in the hope that it will be useful, # but WITHOUT ANY WARRANTY; without even the implied warranty of # MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the # GNU General Public License for more details. # # You should have received a copy of the GNU General Public License # along with this program; if not, write to # # The Free Software Foundation, Inc., # 59 Temple Place - Suite 330, # Boston, MA 02111-1307, USA. package UMLS::Similarity::batet; use strict; use warnings; use UMLS::Similarity; use UMLS::Similarity::ErrorHandler; use vars qw($VERSION); $VERSION = '0.07'; my $debug = 0; sub new { my $className = shift; return undef if(ref $className); if($debug) { print STDERR "In UMLS::Similarity::batet->new()\n"; } my $interface = shift; my $self = {}; # Bless the object. bless($self, $className); # The backend interface object. $self->{'interface'} = $interface; # check the configuration file if defined my $errorhandler = UMLS::Similarity::ErrorHandler->new("batet", $interface); if(!$errorhandler) { print STDERR "The UMLS::Similarity::ErrorHandler did not load properly\n"; exit; } return $self; } sub getRelatedness { my $self = shift; return undef if(!defined $self || !ref $self); my $concept1 = shift; my $concept2 = shift; if($concept1 eq $concept2) { return 1; } # get the interface my $interface = $self->{'interface'}; # get the ancestors of each of the concepts my $ancestors1 = $interface->findAncestors($concept1); my $ancestors2 = $interface->findAncestors($concept2); my $check1 = keys %{$ancestors1}; my $check2 = keys %{$ancestors2}; if($check1 == 0 || $check2 == 0) { return -1; } my %union = (); my %intersection = (); foreach my $cui (sort keys %{$ancestors1}) { if(exists ${$ancestors2}{$cui}) { $intersection{$cui}++; } $union{$cui}++; } foreach my $cui (sort keys %{$ancestors2}) { $union{$cui}++; } # calculate batet my $a = keys %intersection; my $b = keys %union; if($b <= 0) { return -1; } my $score = ($b - $a) / $b; return $score; } 1; __END__ =head1 NAME UMLS::Similarity::batet - Perl module for computing semantic relatedness of concepts in the Unified Medical Language System (UMLS) using the method described by Batet, et al. (2011) =head1 CITATION @article{batet2011ontology, title={An ontology-based measure to compute semantic similarity in biomedicine}, author={Batet, Montserrat and S{\'a}nchez, David and Valls, Aida}, journal={Journal of biomedical informatics}, volume={44}, number={1}, pages={118--125}, year={2011}, publisher={Elsevier} } =head1 SYNOPSIS use UMLS::Interface; use UMLS::Similarity::batet; my $umls = UMLS::Interface->new(); die "Unable to create UMLS::Interface object.\n" if(!$umls); my $batet = UMLS::Similarity::batet->new($umls); die "Unable to create measure object.\n" if(!$batet); my $cui1 = "C0005767"; my $cui2 = "C0007634"; $ts1 = $umls->getTermList($cui1); my $term1 = pop @{$ts1}; $ts2 = $umls->getTermList($cui2); my $term2 = pop @{$ts2}; my $value = $batet->getRelatedness($cui1, $cui2); print "The similarity between $cui1 ($term1) and $cui2 ($term2) is $value\n"; =head1 DESCRIPTION This module computes the semantic relatedness of two concepts in the UMLS according to a method described by Batet et al. (2011). The relatedness measure proposed by Batet, et al. (2011) is =head1 USAGE The semantic relatedness modules in this distribution are built as classes that expose the following methods: new() getRelatedness() =head1 TYPICAL USAGE EXAMPLES To create an object of the batet measure, we would have the following lines of code in the perl program. use UMLS::Similarity::batet; $measure = UMLS::Similarity::batet->new($interface); The reference of the initialized object is stored in the scalar variable '$measure'. '$interface' contains an interface object that should have been created earlier in the program (UMLS-Interface). If the 'new' method is unable to create the object, '$measure' would be undefined. To find the semantic relatedness of the concept 'blood' (C0005767) and the concept 'cell' (C0007634) using the measure, we would write the following piece of code: $relatedness = $measure->getRelatedness('C0005767', 'C0007634'); =head1 CONFIGURATION OPTION The UMLS-Interface package takes a configuration file to determine which sources and relations to use when obtaining the path information. The format of the configuration file is as follows: SAB :: <include|exclude> <source1, source2, ... sourceN> REL :: <include|exclude> <relation1, relation2, ... relationN> For example, if we wanted to use the MSH vocabulary with only the RB/RN relations, the configuration file would be: SAB :: include MSH REL :: include RB, RN or SAB :: include MSH REL :: exclude PAR, CHD If you go to the configuration file directory, there will be example configuration files for the different runs that you have performed. For more information about the configuration options please see the README. =head1 SEE ALSO perl(1), UMLS::Interface perl(1), UMLS::Similarity(3) =head1 CONTACT US If you have any trouble installing and using UMLS-Similarity, please contact us via the users mailing list : umls-similarity@yahoogroups.com You can join this group by going to: http://tech.groups.yahoo.com/group/umls-similarity/ You may also contact us directly if you prefer : Bridget T. McInnes: bthomson at cs.umn.edu Ted Pedersen : tpederse at d.umn.edu =head1 AUTHORS Bridget T McInnes <bthomson at cs.umn.edu> Siddharth Patwardhan <sidd at cs.utah.edu> Serguei Pakhomov <pakh0002 at umn.edu> Ted Pedersen <tpederse at d.umn.edu> =head1 COPYRIGHT AND LICENSE Copyright 2004-2011 by Bridget T McInnes, Siddharth Patwardhan, Serguei Pakhomov and Ted Pedersen This library is free software; you can redistribute it and/or modify it under the same terms as Perl itself. =cut