{
  "resourceType": "Bundle",
  "id": "convert-pheno-fhir-r4-example",
  "type": "collection",
  "timestamp": "2026-07-22T16:22:00Z",
  "entry": [
    {
      "fullUrl": "urn:uuid:5b24c87b-6223-f5b4-51e9-82051159bd1d",
      "resource": {
        "resourceType": "Patient",
        "id": "5b24c87b-6223-f5b4-51e9-82051159bd1d",
        "meta": {
          "profile": [
            "http://hl7.org/fhir/us/core/StructureDefinition/us-core-patient"
          ]
        },
        "extension": [
          {
            "url": "http://hl7.org/fhir/us/core/StructureDefinition/us-core-ethnicity",
            "extension": [
              {
                "url": "ombCategory",
                "valueCoding": {
                  "system": "urn:oid:2.16.840.1.113883.6.238",
                  "code": "2186-5",
                  "display": "Not Hispanic or Latino"
                }
              },
              {
                "url": "text",
                "valueString": "Not Hispanic or Latino"
              }
            ]
          },
          {
            "url": "http://hl7.org/fhir/StructureDefinition/patient-birthPlace",
            "valueAddress": {
              "city": "Winchester",
              "state": "Massachusetts",
              "country": "US"
            }
          }
        ],
        "identifier": [
          {
            "system": "https://github.com/synthetichealth/synthea",
            "value": "5b24c87b-6223-f5b4-51e9-82051159bd1d"
          }
        ],
        "gender": "female",
        "birthDate": "2001-01-06"
      }
    },
    {
      "fullUrl": "urn:uuid:condition-cystitis",
      "resource": {
        "resourceType": "Condition",
        "id": "condition-cystitis",
        "clinicalStatus": {
          "coding": [
            {
              "system": "http://terminology.hl7.org/CodeSystem/condition-clinical",
              "code": "resolved"
            }
          ]
        },
        "verificationStatus": {
          "coding": [
            {
              "system": "http://terminology.hl7.org/CodeSystem/condition-ver-status",
              "code": "confirmed"
            }
          ]
        },
        "code": {
          "coding": [
            {
              "system": "http://snomed.info/sct",
              "code": "307426000",
              "display": "Acute infective cystitis"
            }
          ],
          "text": "Acute infective cystitis"
        },
        "subject": {
          "reference": "urn:uuid:5b24c87b-6223-f5b4-51e9-82051159bd1d"
        },
        "onsetDateTime": "2016-11-04T11:59:46Z",
        "abatementDateTime": "2016-11-05T06:34:13Z"
      }
    },
    {
      "fullUrl": "urn:uuid:observation-glucose",
      "resource": {
        "resourceType": "Observation",
        "id": "observation-glucose",
        "status": "final",
        "category": [
          {
            "coding": [
              {
                "system": "http://terminology.hl7.org/CodeSystem/observation-category",
                "code": "laboratory",
                "display": "Laboratory"
              }
            ]
          }
        ],
        "code": {
          "coding": [
            {
              "system": "http://loinc.org",
              "code": "5792-7",
              "display": "Glucose [Mass/volume] in Urine by Test strip"
            }
          ],
          "text": "Glucose [Mass/volume] in Urine by Test strip"
        },
        "subject": {
          "reference": "Patient/5b24c87b-6223-f5b4-51e9-82051159bd1d"
        },
        "effectiveDateTime": "2016-11-04T13:24:13Z",
        "valueQuantity": {
          "value": 7.6858,
          "unit": "mg/dL",
          "system": "http://unitsofmeasure.org",
          "code": "mg/dL"
        },
        "referenceRange": [
          {
            "low": {
              "value": 0,
              "unit": "mg/dL",
              "system": "http://unitsofmeasure.org",
              "code": "mg/dL"
            },
            "high": {
              "value": 15,
              "unit": "mg/dL",
              "system": "http://unitsofmeasure.org",
              "code": "mg/dL"
            }
          }
        ]
      }
    },
    {
      "fullUrl": "urn:uuid:observation-ketones",
      "resource": {
        "resourceType": "Observation",
        "id": "observation-ketones",
        "status": "final",
        "code": {
          "coding": [
            {
              "system": "http://loinc.org",
              "code": "2514-8",
              "display": "Ketones [Presence] in Urine by Test strip"
            }
          ],
          "text": "Ketones [Presence] in Urine by Test strip"
        },
        "subject": {
          "reference": "Patient/5b24c87b-6223-f5b4-51e9-82051159bd1d"
        },
        "effectiveDateTime": "2016-11-04T13:24:13Z",
        "valueCodeableConcept": {
          "coding": [
            {
              "system": "http://snomed.info/sct",
              "code": "167287002",
              "display": "Urine ketones not detected"
            }
          ],
          "text": "Urine ketones not detected"
        }
      }
    },
    {
      "fullUrl": "urn:uuid:observation-hpo",
      "resource": {
        "resourceType": "Observation",
        "id": "observation-hpo",
        "status": "final",
        "code": {
          "coding": [
            {
              "system": "http://purl.obolibrary.org/obo/hp.owl",
              "code": "HP:0001250",
              "display": "Seizure"
            }
          ],
          "text": "Seizure"
        },
        "subject": {
          "reference": "Patient/5b24c87b-6223-f5b4-51e9-82051159bd1d"
        },
        "effectiveDateTime": "2018-02-10T09:30:00Z",
        "valueBoolean": true
      }
    },
    {
      "fullUrl": "urn:uuid:procedure-immunotherapy",
      "resource": {
        "resourceType": "Procedure",
        "id": "procedure-immunotherapy",
        "status": "completed",
        "code": {
          "coding": [
            {
              "system": "http://snomed.info/sct",
              "code": "180256009",
              "display": "Subcutaneous immunotherapy"
            }
          ],
          "text": "Subcutaneous immunotherapy"
        },
        "subject": {
          "reference": "https://example.org/fhir/Patient/5b24c87b-6223-f5b4-51e9-82051159bd1d"
        },
        "performedPeriod": {
          "start": "2016-08-12T16:28:15Z",
          "end": "2016-08-12T16:52:49Z"
        }
      }
    },
    {
      "fullUrl": "urn:uuid:medication-fexofenadine",
      "resource": {
        "resourceType": "MedicationRequest",
        "id": "medication-fexofenadine",
        "status": "active",
        "intent": "order",
        "medicationCodeableConcept": {
          "coding": [
            {
              "system": "http://www.nlm.nih.gov/research/umls/rxnorm",
              "code": "997488",
              "display": "Fexofenadine hydrochloride 30 MG Oral Tablet"
            }
          ],
          "text": "Fexofenadine hydrochloride 30 MG Oral Tablet"
        },
        "subject": {
          "reference": "Patient/5b24c87b-6223-f5b4-51e9-82051159bd1d"
        },
        "authoredOn": "2017-09-22T12:26:44Z",
        "dosageInstruction": [
          {
            "sequence": 1,
            "text": "Take as needed",
            "asNeededBoolean": true
          }
        ]
      }
    },
    {
      "fullUrl": "urn:uuid:specimen-blood",
      "resource": {
        "resourceType": "Specimen",
        "id": "specimen-blood",
        "status": "available",
        "type": {
          "coding": [
            {
              "system": "http://snomed.info/sct",
              "code": "119297000",
              "display": "Blood specimen"
            }
          ],
          "text": "Blood specimen"
        },
        "subject": {
          "reference": "urn:uuid:5b24c87b-6223-f5b4-51e9-82051159bd1d"
        },
        "receivedTime": "2020-03-21T15:55:00Z",
        "collection": {
          "collector": {
            "display": "Synthetic laboratory"
          },
          "collectedDateTime": "2020-03-21T15:48:03Z",
          "bodySite": {
            "coding": [
              {
                "system": "http://snomed.info/sct",
                "code": "368209003",
                "display": "Right arm"
              }
            ],
            "text": "Right arm"
          }
        }
      }
    },
    {
      "fullUrl": "urn:uuid:observation-hemoglobin",
      "resource": {
        "resourceType": "Observation",
        "id": "observation-hemoglobin",
        "status": "final",
        "category": [
          {
            "coding": [
              {
                "system": "http://terminology.hl7.org/CodeSystem/observation-category",
                "code": "laboratory",
                "display": "Laboratory"
              }
            ]
          }
        ],
        "code": {
          "coding": [
            {
              "system": "http://loinc.org",
              "code": "718-7",
              "display": "Hemoglobin [Mass/volume] in Blood"
            }
          ],
          "text": "Hemoglobin [Mass/volume] in Blood"
        },
        "subject": {
          "reference": "Patient/5b24c87b-6223-f5b4-51e9-82051159bd1d"
        },
        "specimen": {
          "reference": "Specimen/specimen-blood"
        },
        "effectiveDateTime": "2020-03-21T15:48:03Z",
        "valueQuantity": {
          "value": 13.2,
          "unit": "g/dL",
          "system": "http://unitsofmeasure.org",
          "code": "g/dL"
        }
      }
    },
    {
      "fullUrl": "urn:uuid:research-study-1",
      "resource": {
        "resourceType": "ResearchStudy",
        "id": "research-study-1",
        "status": "active",
        "title": "Synthetic FHIR phenotype study",
        "description": "Synthetic study metadata used to test derived Beacon datasets."
      }
    },
    {
      "fullUrl": "urn:uuid:research-subject-1",
      "resource": {
        "resourceType": "ResearchSubject",
        "id": "research-subject-1",
        "status": "on-study",
        "study": {
          "reference": "ResearchStudy/research-study-1"
        },
        "individual": {
          "reference": "Patient/5b24c87b-6223-f5b4-51e9-82051159bd1d"
        }
      }
    },
    {
      "fullUrl": "urn:uuid:research-cohort-1",
      "resource": {
        "resourceType": "Group",
        "id": "research-cohort-1",
        "type": "person",
        "actual": true,
        "name": "Synthetic FHIR study cohort",
        "quantity": 1,
        "member": [
          {
            "entity": {
              "reference": "Patient/5b24c87b-6223-f5b4-51e9-82051159bd1d"
            }
          }
        ]
      }
    }
  ]
}